In the second month, subjects began taking 80 milligrams of pycnogenol daily. Your mileage may vary, depending on your body weight, the brand of arginine you use, etc, etc.. While 40 – 60 mg is said to be effective over long periods, the standard pycnogenol dosage is between 100 – … The 2% group healed nearly 3 days faster than the control. Pine bark extract demonstrates antioxidant and anti-inflammatory actions and has been studied for a wide range of clinical conditions, including asthma, attention deficit hyperactivity disorder (ADHD), chronic venous insufficiency, cardiovascular conditions, diabetes, and erectile dysfuncti… The pycnogenol rats, on the other hand, demonstrated much less decline. These findings suggest that pycnogenol may be effective in wound healing and scar prevention. $33.99 #40. If you want more bang for your buck, this bulk buy will get you the most inexpensive-per-dose pycnogenol supplement. No such changes were noted in the control group. Black seed oil, an extract from a Middle Eastern herb, has similarly been shown to reduce psoriasis symptoms. Symptoms start with very mild vision problems, but can eventually lead to blindness. Research has shown that topical application of pycnogenol cream can help with irritated skin (erythema), which can be caused by things like sunburn.1Pycnogenol, French Maritime Pine Bark Extract It can also help with wound healing, skin hydration, and skin elasticity. A few studies have shown that pycnogenol can be effective in fighting hostile microorganisms, such as bacteria and fungi. Another example is diabetic retinopathy, a condition caused by damaged blood vessels in the back of the eyes. Another study examined the effects of pycnogenol on 100 subjects with knee pain (osteoarthritis).24Effect of pine bark extract (Pycnogenol®) on symptoms of knee osteoarthritis For 3 months, one group supplemented 150 milligrams of pycnogenol daily while the other took a placebo. Other studies using L-arginine and Pycnogenol show similar positive benefits. The dosage varies from as low as 45 mg to the highest point of 450 mg daily. Eradicates the arthritis pain and joint inflammation. If undergoing medical therapies, then consult with your respective Therapist or Health Care Professional about possible interactions between your Treatment, any Pharmaceuticals or Drugs being given, and possible nutritional supplements or practices hosted on Examine.com. A very interesting study found that pycnogenol may help protect the brain following a traumatic brain injury.13Dose- and Time-Dependent Neuroprotective Effects of Pycnogenol® following Traumatic Brain Injury Regardless of dose, the researchers found that administering pycnogenol via IV injection significantly reduced indicators of brain trauma in rats. A meta-analysis of three trials examined the effects of aspirin vs. pycnogenol on blood platelet clumping in smokers.19Inhibition of Smoking-Induced Platelet Aggregation by Aspirin and Pycnogenol Platelet aggregation leads to blood clots, which are helpful for stopping bleeding but are dangerous when they occur in veins and arteries. We obtained a sexual function questionnaire and a sexual activity diary from each patient. Your support allows us to be 100% independent and unbiased. The meta-analysis found that pycnogenol was effective in reducing blood platelet clumping. I'm ready to start making informed decisions about my health, Click here to subscribe to Nutrition Examination Research Digest, https://examine.com/supplements/pycnogenol/, Robust research conducted with repeated double-blind clinical trials, Multiple studies where at least two are double-blind and placebo controlled, Single double-blind study or multiple cohort studies, Uncontrolled or observational studies only. In each dose, the user will be given 100 mg of Pycnogenol, which means that users will end up consuming 200 mg of Pycnogenol every single day. Studies have used twice daily dosing (dividing the daily total into two even doses to be taken with breakfast and dinner) as well as once daily dosing with breakfast. There are many human trials conducted on Pycnogenol, but a good deal of them have industry funding. It’s a fairly inexpensive way to nurture your skin with pycnogenol. For mild high blood pressure, take 200 mg of … Enter your email and we'll keep you on top of the latest nutrition research, supplement myths, and more. BulkSupplements – Pure Pine Bark Extract Capsules. NO was named the "molecule of the year" in … Although there is currently no official recommended dosage, most studies on this supplement have used a daily regimen within that range. For more information on l-arginine and its impact on fertility and sexual health, refer to our complete l-arginine guide. Get our free 5-day course on the essentials of supplementation. 103 unique references to scientific papers. Here are a few ways research has shown that pycnogenol works as a nootropic supplement. manufacturers, food companies, and industry funders. Get 150+ studies summarized for you across 25 different categories every month. This page features 103 references. The maintenance dose is one tablet twice daily. In some cases, vision actually improved. 3 … Solar ultraviolet-induced erythema in human skin and nuclear factor-kappa-B–dependent gene expression in keratinocytes are modulated by a French maritime pine bark extract, An examination of the effects of the antioxidant Pycnogenol® on cognitive performance, serum lipid profile, endocrinological and oxidative stress biomarkers in an elderly population. Prelox contains 60 mg of Pycnogenol, 690 mg of L-arginine and 552 mg of aspartic acid. Procyanidins are chain-like structures consisted of catechins similar to some found in green tea (the green tea catechins that do not have 'gallate' in their names). Supporting these claims, there is indeed some research to suggest pycnogenol may help with melasma. But does science back up the hype? Muchova, J., et al. May be proerectile in persons with organic erectile dysfunction (due to poor blood flow), May increase HDL cholesterol, but has mixed evidence to support it and may be unreliable. With lower levels of alpha-glucosidase, lower blood sugar levels were noted. The team includes nutrition researchers, registered HIGH or Interestingly, this effect was strongest in women who had dry skin before the trial. Pycnogenol is a patented formulation of Pine Bark Extract which is standardized to 65-75% Procyanidin compounds by weight. Following treatment, the pycnogenol group demonstrated a significant reduction in pain, while the control group had no change. One study examined the effects of pycnogenol supplementation in healthy elderly individuals.7An examination of the effects of the antioxidant Pycnogenol® on cognitive performance, serum lipid profile, endocrinological and oxidative stress biomarkers in an elderly population Subjects took 150 milligrams of pycnogenol daily for 3 months. Appears to reduce leg swelling secondary to the enhancement of blood flow. Many people like to use pycnogenol for skin care. A few studies have suggested that pycnogenol may be effective against asthma symptoms. These findings suggest pycnogenol may be effective in treating melasma, with visible improvements in as little as 30 days. On Amazon, the Solgar formula is available for $46.34, which provides the user with a 30-capsule bottle of the supplement. Pycnogenol is fairly popular as a nootropic supplement, a class of supplements that improve cognitive function. Early research shows that taking 50 mg of pycnogenol three times daily for 4 weeks improves circulation and symptoms in people with diabetes. We’ve selected DERMA E moisturizing cream because it has some of the highest levels of pycnogenol Amazon has to offer. But how much of this is marketing puffery, and how much is science? After 8 weeks of pycnogenol supplementation, students demonstrated increased sustained attention compared to a control group. (2014). " Although doses in the range of 40-60mg have been noted to be effective over a prolonged period of time, standard doses of Pycnogenol appear to be in the range of 100-200 mg per day. The usual dosage is 30 to 100 mg/day for maintenance therapy. Several studies have found that pycnogenol may be effective in reducing swelling and inflammation.21Inhibition of NF-κB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol)22Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol). Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry funders. Pycnogenol® supplementation improves cognitive function, attention and mental performance in students. The other group was given a placebo. For treating conditions associated with poor circulation, the dose would be 45 mg to 350 mg daily or 50 mg to 100 mg taken three times daily. This indicates that pycnogenol may be effective in killing or suppressing disease-causing microorganisms, like bacteria and fungi. followed by specifically-applicable references. While the evidence is not overly robust, it is comparable if not better than the reference supplement of, The preliminary evidence at this point in time (promising and independent, but limited) support the usage of pycnogenol in reducing all symptoms of osteoarthritis, reaching up to a halving of symptoms but requiring 90 days for effects to occur, A slight reduction in asthmatic symptoms has been noted with Pycnogenol supplementation, An improvement in attention has been noted, possibly secondary to improvements in general cognition, in students during prolonged academic testing, An improvement in cognitive function has been noted in students during academic testing, A reduction in general oxidation is noted following prolonged Pycnogenol supplementation, May reduce LDL cholesterol for as long as pycnogenol is taken (some evidence to suggest a normalization after supplement cessation), A reduction in pain secondary to improvements in symptoms of osteoarthritis has been noted, and while notable in this certain instance it is not certain if there are inherenet analgesic effects, An improvement in skin elasticity has been noted with Pycnogenol supplementation, Oral supplementation of standard doses of procyanidins can improve skin quality in elderly women, other demographics not tested, An increase in well being and mood has been noted in students undergoing academic testing, which correlated with improved test scores, A decrease in some symptoms of menopause has been noted with Pycnogenol supplementation, No significant alterations in C-Reactive protein noted, No significant alterations in heart rate noted, No significant influence on standard inflammatory cytokines, Despite one study establishing the blood flow effects are dependent on nitric oxide, there do not appear to be any significant differences in nitric oxide quantities in saliva. Pycnogenol … Effect of cigarette smoking on platelet aggregation. Early … Pycnogenol is possibly safe when taken by mouth in doses of 50 mg to 450 mg daily for up to one year, and when applied to the skin as a cream for up to 7 days or as … A typical Pycnogenol skin cream supplement costs $20 at a beauty supply store. Reported side effects of pycnogenol are mild when supplemented in appropriate doses, according to user reports and the above-cited studies.